Detail

The core facility

CYclotron pour la ReCherche et l'Enseignement

Scientifical Manager Ziad EL BITAR
Technical Manager Michel PELLLICIOLI

UMR 7178 - IPHC / Hubert Curien Pluridisciplinary Institute
CNRS, UNIVERSITY OF STRASBOURG

Website of the core facility

Cronenbourg Schiltigheim
Established in an unic site

Service delivery
- to the academic community
- to the socio-economic world

Collaborations of research
- with the academic community
- to the socio-economic world

Affiliated institution of administrative supervision

CNRS
UNIVERSITY OF STRASBOURG

Molecular imaging is an essential tool to study disease development, treatments (drugs, irradiation), biological processes,… in vivo, non-invasively. Thanks to their very high sensitivities, Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) play a central role in this research domain. To perform PET and SPECT imaging we need an isotope (positron emitter or gamma emitter) combined to a molecule of interest, an animal model and a PET or SPECT system. In addition to the imaging facilities, we have two proton beam line (one for detector irradiation and one for biological sample irradiation).

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Expertises

Scientific expertise

Isotopes production
Small animal imaging
Proton irradiation (on materials or biological samples)
Cell cultur
Molecular biology

Technical expertise

Targets irradiation, proton beam managment and design, xenografted mouse model
PET imaging
CT imaging, biodistribution evaluation

Resources

Main equipments

Cyclotron TR24 from ACSI, µTEP-CT IRIS from INVISCAN, homemade irradiation beam lines, SL300 from Hidex

Ministerial autorisations to experiment

Nominative authorisasion for animal testing
Approval of using animals for scientific purposes
Approval of using genetically modified organisms in contained environment

Specific rooms

Laboratory L2
Animal house A2

Software resources / Data bases

Pmod, osirix

Examples of service delivery

Dose delivery on samples (biological, detector) and irradiation of electronic devices using a proton beam line from few fA to sevral µA
We can produce isotps : F-18, Cu-64, Zr-89 and Ga-68
We can determin the distribution of a radioactive molecule ex-vivo
We can do PET imaging on small animal (mice and rats) first injected with PET tracer
We can host mice
We can operate cells culture and molecular biology tests like PCR

Recent collaborative projects

RpPET

Macroscopic study of the efficiency of protontherapy using PET imaging

Find out more

FET as a translational radiotracer in insulinoma

This translational project highlighted the interest of FET radiotracer in insulinoma in vivo and in Human.